Ondansetron compared to promethazine in the treatment of extreme nausea and vomiting in pregnancy (hyperemesis gravidarum)

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  1. Ondansetron compared to promethazine in the treatment of extreme nausea and vomiting in pregnancy (hyperemesis gravidarum)
Population:
Women with extreme nausea and vomiting in pregnancy (hyperemesis gravidarum)
Intervention:
Ondansetron
Comparison:
Promethazine
Outcomes:
Primary outcomes:
• Degree of nausea
• Vomiting
• Inability to tolerate oral fluids or food

Secondary outcomes:
• Hospital treatment
• Health-related quality of life
• Small-for-gestational-age infant
• Preterm birth

What evidence is needed?

More primary research is needed.

What evidence is available?

Reliable systematic reviews that show evidence gaps:

SBU. Behandling av extremt graviditetsillamående (hyperemesis gravidarum): en systematisk översikt [Treatments for extreme nausea and vomiting in pregnancy (hyperemesis gravidarum): a systematic review]. Stockholm: Statens beredning för medicinsk och social utvärdering (SBU); 2022. SBU Utvärderar 355. Read more

Reliable, but not updated, systematic reviews that show evidence gaps:

None identified

Registration number:
Published:
Research conducted after publication could potentially change the nature of the evidence.
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Evidence gap identifies methods or practices for which no conclusive systematic review of benefits and harms has been published. Gaps in scientific evidence appear on the SBU website to help researchers and granting agencies identify areas that are in need of research or systematic review. An additional objective is to offer healthcare and social service providers a basis for setting priorities.